Centrifuge-on-a-chip: Selective Cell Trapping with Rapid Solution Exchange in Microvortices
نویسندگان
چکیده
Here, we present a novel mechanism for cell trapping using microscale laminar vortices containing stable and predictable recirculating fluid flow. Particles larger than the critical size cut-off migrate laterally through fluid streamlines and orbit within the vortex while smaller particles follow fluid streamlines and travel out of the device. Larger particles were measured to experience shear gradient lift forces of up to 0.21μN while entering the vortex. We envision this technique as a method for on-chip rapid exchange of various solutions around cells, that yields a result identical to centrifugation and may prove useful for flow cytometry at the point-of-care.
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